反应详情

N-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-N-methyl-acetamide was reacted with indole boronic acid in general procedure A. Purification on silica yielded 193. NMR: 400 MHz; CDCl3 2.10, 2.18 (3H, s, 2 rotamers); 3.00 (3H, s); 3.84 (4H, m); 4.00 (4H, m); 4.73, 4.77 (2H, s, 2 rotamers); 7.26 (2H, m); 7.33 (1H, s); 7.42 (1H, m); 7.48 (1H, s); 8.13 (1H, m); 8.21 (1H, br s). MS: (ESI+): M+H (422)

1. customPurification on silica