HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → tert-Butyl 3-methanesulfonamidopyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 1-Boc-3-aminopyrrolidine | HCID 2756370 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | tert-Butyl 3-methanesulfonamidopyrrolidine-1-carboxylate | HCID 67189774 | — |
Reaction Steps
To a solution of (+/−)-3-amino-1N—BOC-pyrrolidine (0.5 g) in MeCN (10 mL) was added triethylamine (0.41 mL) then methanesulfonyl chloride (0.22 mL). The mixture was stirred for 2.5 h. An aqueous work-up followed by purification on silica gave 3-methanesulfonylamino-pyrrolidine-1-carboxylic acid tert-butyl ester (0.49 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07846929B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-396bd5aa34ad4feca4e523798be0e3dd |
| Source note | uspto-grants-2010_12 |