反应详情

N-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-N-(1-methyl-pyrrolidin-3-yl)-methanesulfonamide was reacted with 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole in General Procedure A to yield 195. NMR: (CDCl3): 1.96 (1H, m); 2.19 (2H, m); 2.33 (4H, m); 2.48 (1H, m); 2.90 (5H, m); 3.94 (4H, m); 4.10 (4H, m); 4.57 (1H, m); 4.90 (2H, s); 7.50 (1H, s); 7.53 (1H, d, J=7.4 Hz); 7.10 (1H, d, J=8.2 Hz); 8.30 (1H, d, J=7.1 Hz); 9.03 (1H, s); 10.14 (1H, br s). MS: (ESI+): MH+=528