Pyridine-2-carbonyl chloride → N-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)picolinamide

Participants

Role	Name	HCID	Charge
Reactant	Pyridine-2-carbonyl chloride	HCID 135034	—
Reactant	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole	HCID 45480186	—
Reactant	(2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methanamine	HCID 46180727	—
Product	N-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)picolinamide	HCID 59592832	—

Reaction Steps

(2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methanamine 27 was acylated with picolinoyl chloride following General Procedure K and then reacted with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole 7 (34 mg) following General Procedure A to give 287. MS (Q1) 472 (M)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07846929B2
Source dataset	uspto-grants-2010_12
ORD ID	ord-697a638c263b4e06b66371221d8696c9
Source note	uspto-grants-2010_12