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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2262182Generated: October 31, 2026

Pyridine-4-carbonyl chloride → HCID 59592831, compound

https://huagongshe.com/reaction/2262182

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPyridine-4-carbonyl chlorideHCID 417436—
Reactant4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazoleHCID 45480186—
Reactant(2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methanamineHCID 46180727—
ProductHCID 59592831HCID 59592831—

Reaction Steps

(2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methanamine 27 was acylated with isonicotinoyl chloride following General Procedure K and then reacted with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole 7 (34 mg) following General Procedure A to give 290. MS (Q1) 472 (M)+

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07846929B2
Source datasetuspto-grants-2010_12
ORD IDord-e62c6556259f462bad443e1627865c81
Source noteuspto-grants-2010_12