Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(3-Amino-5-(methoxycarbonyl)phenyl)boronic acid → methyl 3-(2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-5-aminobenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (3-Amino-5-(methoxycarbonyl)phenyl)boronic acid | HCID 2737799 | — |
| 반응물 | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole | HCID 45480186 | — |
| 반응물 | 4-(2-Chloro-6-iodothieno[3,2-d]pyrimidin-4-yl)morpholine | HCID 59593061 | — |
| 생성물 | methyl 3-(2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-5-aminobenzoate | HCID 59592844 | — |
반응 단계
2-Chloro-6-iodo-4-morpholinothieno[3,2-d]pyrimidine 19 (50 mg) was coupled to 3-amino-5-methoxycarbonylphenyl boronic acid, and then reacted with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole via General Procedure F. The product was purified by reverse phase HPLC to yield 5.2 mg of 300. MS. (Q1) 487.1 (M)+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07846929B2 |
| 출처 데이터셋 | uspto-grants-2010_12 |
| ORD ID | ord-55742bb1e2fa4404857516a8dac668d7 |
| 출처 메모 | uspto-grants-2010_12 |