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HRID2262209

反应详情

EQUATION

反应方程式

HRID 2262209 的结构方程式

REACTANTS

反应物

3
结构：CCN
HCID6341

Ethanamine

C2H7N

结构：CC1(C)OB(c2cccc3[nH]ncc23)OC1(C)C
HCID45480186

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole

C13H17BN2O2

结构：O=C(O)c1cccc(-c2cc3nc(Cl)nc(N4CCOCC4)c3s2)c1
HCID86618428

未命名化合物

PRODUCTS

生成物

1
结构：CCNC(=O)c1cccc(-c2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)c1
HCID59592851

未命名化合物

PROCEDURE

实验过程

3-(2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)benzoic acid (55 mg) was reacted with ethylamine via General Procedure B to yield 3-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-ethylbenamide. Crude 3-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-ethylbenamide (59 mg) was coupled to 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole 7 via General Procedure A to yield 14.5 mg of 329. MS (Q1) 485.1 (M)+

WORKUP

后处理

  1. customto yield 3-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-ethylbenamide