Methanol → HCID 12751901, compound

HRID 2262259Notes

Reaction equation

HRID 2262259 reaction equation
CS[CH2:3][CH2:4][N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=[O:15].O[O:17][S:18]([O-:20])=O.[K+].[CH3:22]O>O>[CH3:22][S:18]([CH2:3][CH2:4][N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=[O:15])(=[O:20])=[O:17]

Participants

5

Reactant 3

HCID 887MethanolHCID 12751899HCID 12751899, compoundHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 12751901HCID 12751901, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a solution of 2-(2-methylsulfanyl-ethyl)-isoindole-1,3-dione (400 mg) in methanol (10 mL) was added a solution of oxone (1.67 g) in water (10 mL) and the reaction stirred at room temperature for 16 h. The reaction was then diluted with water (20 mL) and extracted into dichloromethane (2×20 mL). The combined organics were washed with aqueous brine solution (2×20 mL), dried (MgSO4) and reduced in vacuo to give 2-(2-methanesulfonyl-ethyl)-isoindole-1,3-dione as a white solid.

Workup

  1. extractionextracted into dichloromethane (2×20 mL)
  2. washThe combined organics were washed with aqueous brine solution (2×20 mL)
  3. dry with materialdried (MgSO4)

Sources & evidence

ORD record
ord-1d1296656ed64494959b3b55167401ab
Source dataset
uspto-grants-2010_12
Patent number
US07846929B2

Reaction notes

Loading…