Methanol → HCID 13459059, compound

HRID 2262263Notes

Reaction equation

HRID 2262263 reaction equation
CS[CH2:3][CH2:4][CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:16].O[O:18][S:19]([O-:21])=O.[K+].[CH3:23]O>O>[CH3:23][S:19]([CH2:3][CH2:4][CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:16])(=[O:21])=[O:18]

Participants

5

Reactant 3

HCID 887MethanolHCID 134589972-[3-(Methylsulfanyl)propyl]-1H-isoindole-1,3(2H)-dioneHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 13459059HCID 13459059, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a solution of 2-(3-methylsulfanyl-propyl)-isoindole-1,3-dione (440 mg) in methanol (10 mL) was added a solution of oxone (1.73 g) in water (10 mL) and the reaction stirred at room temperature for 16 h. The reaction was then diluted with water (20 mL) and extracted into dichloromethane (2×20 mL). The combined organics were washed with aqueous brine solution (2×20 mL), dried (MgSO4) and reduced in vacuo to give 2-(3-methanesulfonyl-propyl)-isoindole-1,3-dione as a white solid.

Workup

  1. extractionextracted into dichloromethane (2×20 mL)
  2. washThe combined organics were washed with aqueous brine solution (2×20 mL)
  3. dry with materialdried (MgSO4)

Sources & evidence

ORD record
ord-ec63c011e2fb47069916147c21f7e919
Source dataset
uspto-grants-2010_12
Patent number
US07846929B2

Reaction notes

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