Phthalimide potassium salt → 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid dimethylamide

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-iodo-propane-1-sulfonic acid dimethylamide (600 mg) in DMF (10 mL) was added potassium phthalimide (590 mg) and the reaction heated at 100° C. for 16 h. After cooling to room temperature, the reaction was partitioned between dichloromethane (30 mL) and water (30 mL). The organic layer was washed with aqueous brine solution (3×30 mL), dried (MgSO4) and reduced in vacuo to give 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid dimethylamide as a white solid.

Provenance & Evidence