Methanesulfonyl chloride → HCID 59593165, compound

Participants

Role	Name	HCID	Charge
Reactant	Methanesulfonyl chloride	HCID 31297	—
Reactant	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole	HCID 45480186	—
Reactant	(2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-methylmethanamine	HCID 59817854	—
Product	HCID 59593165	HCID 59593165	29%

Reaction Steps

1-(2-Chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-methylmethanamine 56 from Example 11b was reacted with methanesulfonylchloride (1.2 eq) followed by Suzuki coupling of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)1H-indazole 7 as per General Procedure K. Complete reaction was confirmed by LCMS and the reaction was concentrated in vacuo to give 31.0 mg of 391 after RP-HPLC purification (29% yield). MS (Q1) 473.2 (M)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07846929B2
Source dataset	uspto-grants-2010_12
ORD ID	ord-80f2a8b2e3724efba3533c749b91b6ff
Source note	uspto-grants-2010_12