Methoxyacetyl chloride → HCID 59592952, compound

Participants

Reaction Steps

1-(2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-methylmethanamine 55 from Example 1a (0.22 g) was reacted with methoxyacetyl chloride (1.2 eq) followed by Suzuki coupling of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)1H-indazole 7 as per General Procedure K. Complete reaction was confirmed by LCMS and the reaction was concentrated in vacuo to give 52.7 mg of 403 after RP-HPLC purification (52% yield). MS (Q1) 453.2 (M)+

Provenance & Evidence