1H-Pyrrolo[2,3-B]pyridin-5-ylboronic acid → N-methyl,N-methylsulfonyl(4-morpholino-2-(1H-pyrrolo[2,3-b]pyridin-5-yl)thieno[2,3-d]pyrimidin-6-yl)methanamine

Participants

Role	Name	HCID	Charge
Reactant	1H-Pyrrolo[2,3-B]pyridin-5-ylboronic acid	HCID 45480257	—
Reactant	N-((2-chloro-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)-N-methylmethanesulfonamide	HCID 56834050	—
Product	N-methyl,N-methylsulfonyl(4-morpholino-2-(1H-pyrrolo[2,3-b]pyridin-5-yl)thieno[2,3-d]pyrimidin-6-yl)methanamine	HCID 59593077	6%

Reaction Steps

(2-Chloro-4-morpholinothieno[2,3-d]pyrimidin-6-yl-n-methyl-N-(methylsulfonyl)methaneamine and 1H-pyrrolo[2,3-b]pyridin-5-yl-5-boronic acid were reacted following General Procedure A to produce 417 in 6.0% yield MS (Q1) 459.2 (M)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07846929B2
Source dataset	uspto-grants-2010_12
ORD ID	ord-9d588031dcac42c1bb149c40b5a1a680
Source note	uspto-grants-2010_12