Dichloromethane → N-(2-diethylamino-ethyl)-4-(methanesulfonylamino)-2-methoxy-benzamide

HRID 2262354Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2262354
[CH2:1]([N:3]([CH2:26][CH3:27])[CH2:4][CH2:5][NH:6][C:7](=[O:25])[C:8]1[CH:13]=[CH:12][C:11]([N:14](S(C)(=O)=O)[S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][C:9]=1[O:23][CH3:24])[CH3:2].[OH-].[K+].C(=O)(O)[O-].[Na+].C(Cl)Cl>O1CCCC1>[CH2:26]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][NH:6][C:7](=[O:25])[C:8]1[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:16])=[O:17])=[CH:10][C:9]=1[O:23][CH3:24])[CH3:27]

Komponenten

6

Edukt 4

HCID 6344DichloromethaneHCID 14797Potassium HydroxideHCID 516892Sodium BicarbonateHCID 66934940N-(2-diethylamino-ethyl)-4-(bismethanesulfonylamino)-2-methoxy-benzamide

Produkt 1

HCID 16748090N-(2-diethylamino-ethyl)-4-(methanesulfonylamino)-2-methoxy-benzamideAusbeute 92,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

150 mg (0.36 mmol) of N-(2-diethylamino-ethyl)-4-(bismethanesulfonylamino)-2-methoxy-benzamide is dissolved in 10 ml of tetrahydrofuran and mixed with 1 ml of 1N potassium hydroxide solution. It is stirred for 2 hours at room temperature. Then, the tetrahydrofuran is drawn off in a vacuum, mixed with 25 ml of saturated sodium bicarbonate solution and shaken out three times with 25 ml each of methylene chloride. The collected organic phase is dried, filtered and concentrated by evaporation, and 114 mg (91.9% of theory) of N-(2-diethylamino-ethyl)-4-(methanesulfonylamino)-2-methoxy-benzamide is obtained.

Aufarbeitung

  1. customThe collected organic phase is dried
  2. filtrationfiltered
  3. concentrationconcentrated by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-bfb712aa38274f6abd5f882479b1f350
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07850948B2

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