HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dimethoxyethane → 2-(4'-tert-Butyl[1,1'-biphenyl]-3-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dimethoxyethane | HCID 8071 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-tert-Butylphenylboronic acid | HCID 2734320 | — |
| Reactant | 2-(3-Bromophenyl)pyridine | HCID 11115506 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(4'-tert-Butyl[1,1'-biphenyl]-3-yl)pyridine | HCID 59594038 | — |
Reaction Steps
13.7 g (0.058 mol) of 2-(3-bromophenyl)pyridine was added to 12.5 g (0.070 mol) of 4-tert-butylphenylboronic acid, 3.4 g (0.003 mol) of Pd(Ph3)4, 22.0 g (0.16 mol) of K2CO3, 50 mL of DME and 50 mL of water. The reaction mixture was refluxed for 20 hours and separated on silica gel column. MS confirmed the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07851072B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-3170449e07604f0e92e3a686d5cfad5a |
| Source note | uspto-grants-2010_12 |