反应详情

0.76 g (4.076 mmol) of anilinopyridone 2 and 1.008 g (4.076 mmol) of ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate are added successively with stirring at room temperature to 1.0 g (4.076 mmol) of BOC-methoxyproline 1 as a suspension in 15 ml of toluene. The mixture is subsequently stirred at this temperature for 18 hours and then subjected to conventional work-up, giving 1.53 g (90.8%) of BOC-proline anilide derivative 3 as crude product; MS-EI (M+) 414.