Toluene → HCID 86761229, compound

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Reaction Steps

The above-obtained 3′,5′-bis-O-(tert-butyldimethylsilyl)-2-N-carbamoyl-6-O-diphenylcarbamoyldeoxyguanosine (1.53 g, 2.09 mmol) was azeotroped with anhydrous tetrahydrofuran three times and dissolved in anhydrous tetrahydrofuran (10 mL), and triethylamine 3 hydrogen fluoride (1.02 mL, 6.27 mmol) was added thereto. The mixture was stirred at room temperature overnight, and then toluene (10 mL) was added thereto. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (N60: spherical neutral silica gel) with methanol/4% to 10% chloroform to give 2-N-carbamoyl-6-O-diphenylcarbamoyldeoxyguanosine (1.21 g, quant).

Provenance & Evidence