HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 86059762, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Iodoacetonitrile | HCID 69356 | — |
| Reactant | 2,6-PIPERIDINEDIMETHANOL | HCID 5247464 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86059762 | HCID 86059762 | 53% |
Reaction Steps
The method follows that of S5. 2,6-piperidinedimethanol (3.80 g, 26.21 mmol), iodoacetonitrile (5.24 g, 31.45 mmol), Et3N (4.38 mL, 31.45 mmol) and dry DMF (20 mL). Purification by flash chromatography using CH2Cl2/CH3OH (9:1) as eluent afforded the title compound as a straw-coloured oil (2.5 g, 53%). FAB MS, m/z(M+H)+ 185.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557215B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-7325b012c0aa41718db050f3cc535829 |
| Source note | uspto-grants-2009_07 |