HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-N-Boc-2-hydroxymethylmorpholine → (R)-4-Methyl-2-(hydroxymethyl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-N-Boc-2-hydroxymethylmorpholine | HCID 1512576 | — |
| Reactant | tert-Butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate | HCID 1512577 | — |
| Product | (R)-4-Methyl-2-(hydroxymethyl)morpholine | HCID 40152301 | — |
Reaction Steps
(R)-(4-Methylmorpholin-2-yl)-methanol was prepared similar to the procedure described for Intermediate 10, but using (R)-2-hydroxymethyl-morpholine-4-carboxylic acid tert-butyl ester (Intermediate 9) instead of (S)-2-hydroxymethyl-morpholine-4-carboxylic acid tert-butyl ester (Intermediate 8). The title compound was obtained as a colourless oil (560 mg, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07851471B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-9559d207592e41a0be638dc1a9a5e56d |
| Source note | uspto-grants-2010_12 |