HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorophenylboronic acid → 4-[1-(4-Fluoro-phenyl)-1H-imidazol-4-yl]-3-phenyl-5-trifluoromethyl-isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Reactant | HCID 178506308 | HCID 178506308 | — |
| Product | 4-[1-(4-Fluoro-phenyl)-1H-imidazol-4-yl]-3-phenyl-5-trifluoromethyl-isoxazole | HCID 25130450 | 52% |
Reaction Steps
As described for Example 1j, 4-(1H-imidazol-4-yl)-3-phenyl-5-trifluoromethyl-isoxazole (100 mg, 0.36 mmol) was converted, using 4-fluorophenylboronic acid instead of phenylboronic acid, to the title compound (70 mg, 52%) which was obtained as a white solid. MS: m/e=374.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07851469B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-e7dff650c0124e3cae73c1fb1d0b9e7a |
| Source note | uspto-grants-2010_12 |