HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tolylboronic acid → 3-Phenyl-4-(1-p-tolyl-1H-imidazol-4-yl)-5-trifluoromethyl-isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tolylboronic acid | HCID 79799 | — |
| Reactant | HCID 178506308 | HCID 178506308 | — |
| Product | 3-Phenyl-4-(1-p-tolyl-1H-imidazol-4-yl)-5-trifluoromethyl-isoxazole | HCID 25130785 | 42% |
Reaction Steps
As described for Example 1j, 4-(1H-imidazol-4-yl)-3-phenyl-5-trifluoromethyl-isoxazole (100 mg, 0.36 mmol) was converted, using p-tolylboronic acid instead of phenylboronic acid, to the title compound (55 mg, 42%) which was obtained as a white solid. MS (ESI): m/e=370.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07851469B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-6b321ea698e14101b699feb2437f326d |
| Source note | uspto-grants-2010_12 |