Ethanamine, 2,2,2-trifluoro- → HCID 25132479, compound

HRID 2262546Notes

Reaction equation

HRID 2262546 reaction equation
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[C:13]([C:15]3[C:16]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[N:17][O:18][C:19]=3[C:20]([F:23])([F:22])[F:21])[N:12]=[CH:11]2)=[N:6][CH:5]=1.[F:31][C:32]([F:36])([F:35])[CH2:33][NH2:34]>>[C:24]1([C:16]2[C:15]([C:13]3[N:12]=[CH:11][N:10]([C:7]4[CH:8]=[CH:9][C:4]([C:3]([NH:34][CH2:33][C:32]([F:36])([F:35])[F:31])=[O:2])=[CH:5][N:6]=4)[CH:14]=3)=[C:19]([C:20]([F:22])([F:21])[F:23])[O:18][N:17]=2)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 25132124HCID 25132124, compound

Product 1

HCID 25132479HCID 25132479, compoundYield 57%

Procedure

As described for Example 18, 6-[4-(3-phenyl-5-trifluoromethyl-isoxazol-4-yl)-imidazol-1-yl]-nicotinic acid methyl ester (90 mg, 0.22 mmol), was converted, using 2,2,2-trifluoroethylamine instead of cyclopropanemethylamine, to the title compound (60 mg, 57%) which was obtained as a white solid. MS: m/e=482.1 [M+H]+.

Sources & evidence

ORD record
ord-3c71fcabdc484c00903e1b140fa5c166
Source dataset
uspto-grants-2010_12
Patent number
US07851469B2

Reaction notes

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