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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2262550Generated: November 2, 2026

Thiomorpholine → HCID 25132818, compound

https://huagongshe.com/reaction/2262550

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThiomorpholineHCID 67164—
ReactantHCID 25132124HCID 25132124—
ProductHCID 25132818HCID 2513281851%

Reaction Steps

As described for Example 18, 6-[4-(3-phenyl-5-trifluoromethyl-isoxazol-4-yl)-imidazol-1-yl]-nicotinic acid methyl ester (70 mg, 0.17 mmol), was converted, using thiomorpholine instead of cyclopropanemethylamine, to the title compound (42 mg, 51%) which was obtained as a colourless oil. MS: m/e=486.0 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07851469B2
Source datasetuspto-grants-2010_12
ORD IDord-6c3b9dcf04b64a548f2adc979eae0cc7
Source noteuspto-grants-2010_12