Methyl 4-fluorobenzoate → HCID 25131432, compound

HRID 2262558Notes

Reaction equation

HRID 2262558 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[N:14]=[CH:15][NH:16][CH:17]=3)=[C:11]([C:18]([F:21])([F:20])[F:19])[O:10][N:9]=2)=[CH:4][CH:3]=1.F[C:23]1[CH:32]=[CH:31][C:26]([C:27]([O:29]C)=[O:28])=[CH:25][CH:24]=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[N:14]=[CH:15][N:16]([C:23]4[CH:32]=[CH:31][C:26]([C:27]([OH:29])=[O:28])=[CH:25][CH:24]=4)[CH:17]=3)=[C:11]([C:18]([F:21])([F:19])[F:20])[O:10][N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 67878Methyl 4-fluorobenzoateHCID 178505600HCID 178505600, compound

Product 1

HCID 25131432HCID 25131432, compoundYield 15%

Procedure

As described for Example 24, 3-(4-fluoro-phenyl)-4-(1H-imidazol-4-yl)-5-trifluoromethyl-isoxazole (900 mg, 3.0 mmol), using methyl 4-fluorobenzoate instead of 4-fluoroacetophenone, was converted to the title compound (190 mg, 15%) which was obtained as a white solid. MS: m/e=416.3 [M+H]+.

Sources & evidence

ORD record
ord-9d38f83b07ff4ef8a5380c1be2b15ccd
Source dataset
uspto-grants-2010_12
Patent number
US07851469B2

Reaction notes

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