HCID 25130783, compound → HCID 25131773, compound

HRID 2262562Notes

Reaction equation

HRID 2262562 reaction equation
CO[C:3](=[O:31])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[C:13]([C:15]3[C:16]([C:24]4[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=4)=[N:17][O:18][C:19]=3[C:20]([F:23])([F:22])[F:21])[N:12]=[CH:11]2)=[CH:6][CH:5]=1.COC(=O)C1C=CC(N2C=C(C3[C:47]([C:55]4[CH:60]=[CH:59]C=CC=4)=[N:48]OC=3C(F)(F)F)N=C2)=CC=1>>[CH:55]1([CH2:47][NH:48][C:3](=[O:31])[C:4]2[CH:9]=[CH:8][C:7]([N:10]3[CH:14]=[C:13]([C:15]4[C:16]([C:24]5[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=5)=[N:17][O:18][C:19]=4[C:20]([F:21])([F:23])[F:22])[N:12]=[CH:11]3)=[CH:6][CH:5]=2)[CH2:60][CH2:59]1

Participants

3

Reactant 2

HCID 25130783HCID 25130783, compoundHCID 25131431HCID 25131431, compound

Product 1

HCID 25131773HCID 25131773, compoundYield 69%

Procedure

As described for Example 10, 4-{4-[3-(4-fluoro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-imidazol-1-yl}-benzoic acid methyl ester (100 mg, 0.23 mmol), instead of 4-[4-(3-phenyl-5-trifluoromethyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid methyl ester was converted, to the title compound (75 mg, 69%) which was obtained as a white solid. MS: m/e=471.0 [M+H]+.

Sources & evidence

ORD record
ord-09367d3b74da439d990944eeb24b03db
Source dataset
uspto-grants-2010_12
Patent number
US07851469B2

Reaction notes

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