Ethanamine, 2,2,2-trifluoro- → HCID 25132822, compound

HRID 2262568Notes

Reaction equation

HRID 2262568 reaction equation
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[C:13]([C:15]3[C:16]([C:24]4[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=4)=[N:17][O:18][C:19]=3[C:20]([F:23])([F:22])[F:21])[N:12]=[CH:11]2)=[N:6][CH:5]=1.[F:32][C:33]([F:37])([F:36])[CH2:34][NH2:35]>>[F:30][C:27]1[CH:28]=[CH:29][C:24]([C:16]2[C:15]([C:13]3[N:12]=[CH:11][N:10]([C:7]4[CH:8]=[CH:9][C:4]([C:3]([NH:35][CH2:34][C:33]([F:37])([F:36])[F:32])=[O:2])=[CH:5][N:6]=4)[CH:14]=3)=[C:19]([C:20]([F:23])([F:21])[F:22])[O:18][N:17]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 67363061HCID 67363061, compound

Product 1

HCID 25132822HCID 25132822, compoundYield 95.8%

Procedure

As described for Example 38b, 6-{4-[3-(4-fluoro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-imidazol-1-yl}-nicotinic acid methyl ester (100 mg, 0.23 mmol), was converted, using 2,2,2-trifluoroethylamine (74.19 μL, 0.9 mmol) instead of cyclopropanemethylamine, to the title compound (110 mg, 95%) which was obtained as a white solid. MS: m/e=499.8 [M+H]+.

Sources & evidence

ORD record
ord-0d550951022c4fe9a739255e0b183c2f
Source dataset
uspto-grants-2010_12
Patent number
US07851469B2

Reaction notes

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