HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Hydroxy-3-phenyl-5-(trifluoromethyl)-4,5-dihydroisoxazole → 3-(4-Chlorophenyl)-5-(trifluoromethyl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Hydroxy-3-phenyl-5-(trifluoromethyl)-4,5-dihydroisoxazole | HCID 2880976 | — |
| Reactant | 3-(4-Chloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-ol | HCID 2881161 | — |
| Product | 3-(4-Chlorophenyl)-5-(trifluoromethyl)isoxazole | HCID 799321 | 98% |
Reaction Steps
As described for Example 1b, 3-(4-chloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-ol (39.6 g, 149 mmol), instead of 3-phenyl-5-hydroxy-5-(trifluoromethyl)isoxazoline, was converted to the title compound (36.0 g, 98%) which was obtained as a light brown oil. MS: m/e=247.3 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07851469B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-c837689e58f8465fb3ea26fde94cd2c7 |
| Source note | uspto-grants-2010_12 |