HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-Fluoroacetophenone → HCID 25132119, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-Fluoroacetophenone | HCID 9828 | — |
| Reactant | Benzene, 1-fluoro-4-(trifluoromethyl)- | HCID 67873 | — |
| Reactant | HCID 178506308 | HCID 178506308 | — |
| Reactant | HCID 178506309 | HCID 178506309 | — |
| Product | HCID 25132119 | HCID 25132119 | 44% |
Reaction Steps
As described for Example 4, 3-(4-chloro-phenyl)-4-(1H-imidazol-4-yl)-5-trifluoromethyl-isoxazole (100 mg, 0.32 mmol) and 4-fluoroacetophenone, instead of 4-(1H-imidazol-4-yl)-3-phenyl-5-trifluoromethyl-isoxazole and 4-fluorobenzotrifluoride, was converted to the title compound (60 mg, 44%) which was obtained as a light brown solid. MS: m/e=432.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07851469B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-eedc222eb0864ca6b4747312bbcaaf66 |
| Source note | uspto-grants-2010_12 |