HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Hydroxy-3-phenyl-5-(trifluoromethyl)-4,5-dihydroisoxazole → 3-(3-Fluoro-phenyl)-5-trifluoromethyl-isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Hydroxy-3-phenyl-5-(trifluoromethyl)-4,5-dihydroisoxazole | HCID 2880976 | — |
| Reactant | 3-(3-Fluoro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-ol | HCID 67362753 | — |
| Product | 3-(3-Fluoro-phenyl)-5-trifluoromethyl-isoxazole | HCID 67362813 | 85.3% |
Reaction Steps
As described for Example 1b, 3-(3-fluoro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-ol (60 g, 241 mmol), instead of 3-phenyl-5-hydroxy-5-(trifluoromethyl)isoxazoline, was converted to the title compound (47.5 g, 85%) which was obtained as a light brown solid. MS: m/e=231.1 [M]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07851469B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-b4382e3342574a4e856447a4835b2022 |
| Source note | uspto-grants-2010_12 |