3-phenyl-4-(1-phenyl-1H-imidazol-4-yl)-5-trifluoromethyl-isoxazole → 1-[3-(3-Fluoro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-ethanone

Participants

Reaction Steps

As described for Example 1e, 3-(3-fluoro-phenyl)-5-trifluoromethyl-isoxazole (20 g, 86.5 mmol), instead of 3-phenyl-4-(1-phenyl-1H-imidazol-4-yl)-5-trifluoromethyl-isoxazole, was converted to the title compound (12.2 g, 51%) which was obtained as a light yellow oil. MS: m/e=272.1 [M−H]−.

Provenance & Evidence