2-Chloropyrimidine → HCID 25133493, compound

HRID 2262587Notes

Reaction equation

[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[N:8][O:9][C:10]=2[C:11]([F:14])([F:13])[F:12])[N:3]=[CH:2]1.Cl[C:22]1[N:27]=[CH:26][CH:25]=[CH:24][N:23]=1>>[C:15]1([C:7]2[C:6]([C:4]3[N:3]=[CH:2][N:1]([C:22]4[N:27]=[CH:26][CH:25]=[CH:24][N:23]=4)[CH:5]=3)=[C:10]([C:11]([F:14])([F:12])[F:13])[O:9][N:8]=2)[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

Reactant 2

HCID 744042-Chloropyrimidine

HCID 178506308HCID 178506308, compound

Product 1

HCID 25133493HCID 25133493, compoundYield 35%

Procedure

As described for Example 4, 4-(1H-imidazol-4-yl)-3-phenyl-5-trifluoromethyl-isoxazole (67.4 mg, 0.48 mmol) was converted, using 2-chloropyrimidine instead of 4-fluorobenzotrifluoride, to the title compound (40 mg, 35%) which was obtained as a white solid. MS: m/e=358.2 [M+H]+.

Sources & evidence

ORD record: ord-d208b28a36734f4b9b78ecb093f23910
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07851469B2

Reaction notes

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