HCID 60205207, compound → HCID 67071268, compound

HRID 2262606Notes

Reaction equation

HRID 2262606 reaction equation
C([N:8]1[CH2:12][CH2:11][CH:10]([C:13]2[N:18]=[CH:17][C:16]([NH:19][S:20]([C:23]3[CH:28]=[CH:27][C:26]([CH:29]([CH3:31])[CH3:30])=[CH:25][CH:24]=3)(=[O:22])=[O:21])=[CH:15][CH:14]=2)[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[NH:8]1[CH2:12][CH2:11][CH:10]([C:13]2[N:18]=[CH:17][C:16]([NH:19][S:20]([C:23]3[CH:24]=[CH:25][C:26]([CH:29]([CH3:31])[CH3:30])=[CH:27][CH:28]=3)(=[O:22])=[O:21])=[CH:15][CH:14]=2)[CH2:9]1

Participants

4

Reactant 1

HCID 60205207HCID 60205207, compound

Product 1

HCID 67071268HCID 67071268, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

0.12 g of N-[6-(1-benzyl-pyrrolidin-3-yl)-pyridin-3-yl]-4-isopropyl-benzene-sulfonamide (0.28 mmol) were dissolved in 20 ml of methanol, a tip of a spatula 10% Pd/C was added, and the reaction mixture was hydrogenated for 2 h at room temperature and 4 h at 50° C. The catalyst was removed by filtration and the filtrate evaporated to dryness to yield 0.088 g of the desired debenzylated compound.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated to dryness
  3. customto yield 0.088 g of the desired debenzylated compound

Sources & evidence

ORD record
ord-74b618d540ff4dfead579981931ad86a
Source dataset
uspto-grants-2010_12
Patent number
US07851463B2

Reaction notes

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