4-Bromophenol → HCID 24705025, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 12.75 g (77.73 mmol) of 3-chloromethyl)pyridine hydrochloride, 13.45 g (77.73 mmol) of 4-bromophenol and 27.6 g (200 mmol) of potassium carbonate in 100 ml of methyl ethyl ketone is stirred at room temperature for 24 hr and at 60° C. for 4 hr. The solids are filtered and the filtrate is concentrated. The residue is partitioned between water and diethyl ether. The ethereal layer is washed with 2N NaOH and water, and is dried and concentrated. The resulting oil (12.9 g, 49% yield) solidifies on cooling.

Provenance & Evidence