HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → (2-Acetyl-4-methoxy-phenoxy)-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(2-Hydroxy-5-methoxyphenyl)ethan-1-one | HCID 69714 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | (2-Acetyl-4-methoxy-phenoxy)-acetic acid ethyl ester | HCID 15643798 | — |
Reaction Steps
A mixture of 16.6 g (100.0 mmol) of 2-hydroxi-5-methoxyacetophenone, 20 g (208 mmol) of potassium carbonate, 16.7 g (100.0 mmol) of ethyl bromoacetate and 200 ml of MEK is stirred at reflux temperature for 10 hr. The solids are filtered and the filtrate concentrated. The residue is suspended in water and the solid is filtered and dried. Yield: 10.2 g (40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557212B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-60bd36e5ee7d4e22abc36d0cbb75c24c |
| Source note | uspto-grants-2009_07 |