HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-((S)-2-Fluoro-1-methyl-ethyl)-benzenesulfonyl chloride → 4-((S)-2-Fluoro-1-methyl-ethyl)-N-[4-(1-propyl-azetidin-3-yl)-phenyl]-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-((S)-2-Fluoro-1-methyl-ethyl)-benzenesulfonyl chloride | HCID 53628600 | — |
| Reactant | HCID 57470084 | HCID 57470084 | — |
| Solvent | Pyridine methylene chloride | HCID 21875418 | — |
| Product | 4-((S)-2-Fluoro-1-methyl-ethyl)-N-[4-(1-propyl-azetidin-3-yl)-phenyl]-benzenesulfonamide | HCID 67071391 | 22.5% |
Reaction Steps
Following the same procedure as described in example 55, 4-(1-propyl-azetidin-3-yl)phenylamine (110 mg, 0.57 mmol) in CH2Cl2/pyridine 1:1 (12 ml) was treated with 4-((S)-2-fluoro-1-methyl-ethyl)-benzenesulfonyl chloride (178 mg, 0.75 mmol). Purification of the crude product by flash column chromatography (CH2Cl2:methanol, 95:5) provided the title compound (50 mg, 22%) as a gum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07851463B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-936931f218464d04a1cbf87fbf37870d |
| Source note | uspto-grants-2010_12 |