反应详情

温度

60 °C

A mixture of 10.0 g (23.76 mmol) of the product from Example 23, step 7, 9.7 g (52.3 mmol) of L-cystein ethyl ester hydrochloride and 105 ml of trifluoroacetic acid is stirred at 60° C. for 48 hr. The solvent is evaporated and the residue partitioned between sat. NaHCO3 and chloroform. The organic layer is washed with water, dried and concentrated, giving an oil, which is crystallised from ethyl ether/diisopropyl ether. Yield 10.4 g (80%).

1. customThe solvent is evaporated
2. customthe residue partitioned between sat. NaHCO3 and chloroform
3. washThe organic layer is washed with water
4. customdried
5. concentrationconcentrated
6. customgiving an oil, which
7. customis crystallised from ethyl ether/diisopropyl ether