Potassium Carbonate → HCID 15548678, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of tert-butyl 4-[benzyl(2-iodobenzoyl)amino]-3,6-dihydropyridine-1(2H)-carboxylate (4.63 mmol), Pd(OAc)2 (73 mg, 0.32 mmol, 7 mol %), PPh3 (170 mg, 0.65 mmol, 14 mol %), K2CO3 (959 mg, 6.95 mmol) and Et4NCl (537 mg, 3.24 mmol) in CH3CN (30 ml) is degassed by Argon for 15 min then heated at 110° C. in a sealed tube overnight. Water (40 ml) is added, the layers are separated and the aqueous layer is extracted with EtOAc (40 ml). The combined extracts are washed with brine (40 ml), dried over Na2SO4 and evaporated. The residue is purified by flash column to give the title compound as a light yellow oil.

Provenance & Evidence