4-Fluoro-3-nitrobenzoic acid → 3-Nitro-4-(3-thiazol-2-yl-phenylamino)benzoic acid

Participants

Reaction Steps

To a solution of 3-thiazol-2-yl-phenylamine (14.0 g, 79 mmol) in anhydrous NMP (50 ml) was added 4-fluoro-3-nitrobenzoic acid (15.0 g, 127 mmol). The resultant mixture was stirred at 90° C. over night. The cooled reaction cake was suspended in water and the solid was filtered off, washed with water and dried in the air to afford the desired product (22.5 g, 83%).

Provenance & Evidence