1,3-Propanediol → HCID 67484042, compound

Participants

Reaction Steps

A mixture of 2-[1-(3-bromophenyl)-1H-benzimidazol-5-ylmethyl]-isoindole-1,3-dione (1.10 g, 2.54 mmol), 3-pyridineboronic acid (0.47 g, 3.82 mmol), potassium carbonate (1.06 g, 7.63 mmol), 1,3-propanediol (0.92 ml, 12.72 mmol) and dichlorobis(triphenylphosphine)palladium(II) (0.1 g) in a mixture of dimethoxyethane (20 ml) and water (10 ml) was stirred at reflux in a nitrogen atmosphere for 20 min. The resultant mixture was cooled and volatile material was removed in vacuo. The product precipitated from the residual solvent and was filtered off, washed with water and dried in the air to afford 0.56 g.

Provenance & Evidence