HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 1-(1-(3-bromophenyl)-1H-benzo[d]imidazol-5-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 1-[3-Amino-4-(3-bromo-phenylamino)-phenyl]-ethanone | HCID 53988946 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(1-(3-bromophenyl)-1H-benzo[d]imidazol-5-yl)ethanone | HCID 54030307 | — |
Reaction Steps
This was prepared from 1-[3-amino-4-(3-bromo-phenylamino)-phenyl]-ethanone (86.5 g, 0.28 mol) by treatment with triethyl orthoformate in THF in the presence of p-toluenesulfonic acid as described in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07851490B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-a1b5c198050f45bb8d5cbcb3a7a1ed36 |
| Source note | uspto-grants-2010_12 |