Sodium borohydride → HCID 57572241, compound

Participants

Reaction Steps

To a solution of 1-{1-[3-(5-chloro-thiazol-2-yl)-phenyl]-1H-benzoimidazol-5-yl}-ethanone (6.3 g, 17.8 mmol) in methanol (75 ml) was added sodium borohydride (0.91 g, 23.9 mmol) and the resultant mixture was stirred at room temperature in a nitrogen atmosphere for 7 days. The reaction mixture was diluted with four volumes of water and extracted with ethyl acetate. The organic extract was washed with brine, dried over magnesium sulphate and evaporated in vacuo to leave the desired product (4.95 g, 78%). LC-ESI-HRMS of [M+H]+ shows 356.0635 Da. Calc. 356.062436 Da. dev. 3 ppm.

Provenance & Evidence