HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2,4-Dimethoxypyrimidin-5-yl)boronic acid → N-(1-{1-[3-(2,4-Dimethoxy-pyrimidin-5-yl)-phenyl]-1H-benzoimidazol-5-yl}-ethyl)-formamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2,4-Dimethoxypyrimidin-5-yl)boronic acid | HCID 2736209 | — |
| Reactant | N-{1-[1-(3-Bromo-phenyl)-1H-benzoimidazol-5-yl]-ethyl}-formamide | HCID 57572242 | — |
| Product | N-(1-{1-[3-(2,4-Dimethoxy-pyrimidin-5-yl)-phenyl]-1H-benzoimidazol-5-yl}-ethyl)-formamide | HCID 11983416 | 81% |
Reaction Steps
This was prepared analogously from N-{1-[1-(3-bromo-phenyl)-1H-benzoimidazol-5-yl]-ethyl}-formamide and 2,4-dimethoxypyrimidine-5-boronic acid in 81% yield. LC-ESI-HRMS of [M+H]+ shows 404.1729 Da. Calc. 404.172265 Da. dev. 1.6 ppm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07851490B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-07ff8af0a5074ac5a47c752c04823d9c |
| Source note | uspto-grants-2010_12 |