3-(Trifluoromethyl)phenyl isocyanate → HCID 11315379, compound

HRID 2262763Notes

Reaction equation

HRID 2262763 reaction equation
N1C=CC=NC=1NC(NC1C=CC=CC=1C(F)(F)F)=O.[NH2:21][C:22]1[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:23]=1[S:29]([NH2:32])(=[O:31])=[O:30].[F:33][C:34]([F:45])([F:44])[C:35]1[CH:36]=[C:37]([N:41]=[C:42]=[O:43])[CH:38]=[CH:39][CH:40]=1>>[Cl:28][C:26]1[CH:25]=[CH:24][C:23]([S:29]([NH2:32])(=[O:31])=[O:30])=[C:22]([NH:21][C:42]([NH:41][C:37]2[CH:38]=[CH:39][CH:40]=[C:35]([C:34]([F:33])([F:44])[F:45])[CH:36]=2)=[O:43])[CH:27]=1

Participants

4

Reactant 3

HCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 777902-Amino-4-chlorobenzenesulphonamideHCID 310581HCID 310581, compound2×

Product 1

HCID 11315379HCID 11315379, compound

Procedure

This compound was prepared in a manner analogous to 1-Pyrimidin-2-yl-3-(2-trifluoromethyl-phenyl)-urea (Compound 2) from 2-amino-4-chloro-benzenesulfonamide and 3-trifluoromethylphenylisocyanate, yielding 4-chloro-2-[3-(3-trifluromethyl-phenyl)-ureido]-benzenesulfonamide (550 mg). Mp.=163-165° C.

Sources & evidence

ORD record
ord-436b624978264b17a45618836958faa6
Source dataset
uspto-grants-2010_12
Patent number
US07851492B2

Reaction notes

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