1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → HCID 178484524, compound

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Reaction Steps

3-[4-Amino-3-(1H-tetrazol-5-yl)-phenyl]-N,N-dimethyl-propionamide (90 mg) dissolved in acetonitrile at 65° C. under Ar was treated with 4-chloro-3-trifluoromethylphenylisocyanate (85.6 mg) and the mixture was stirred overnight. Cooling to room temperature and filtration afforded 3-[4-[3-(4-chloro-3-trifluoromethyl-phenyl)-ureido]-3-(1H-tetrazol-5-yl)-phenyl]-N,N-dimethyl-propionamide. Mp.=184.5-189.3° C.

Provenance & Evidence