3,5-Dichlorophenyl isocyanate → HCID 178522179, compound

Participants

Reaction Steps

4-Chloro-2-(1H-tetrazol-5-yl)-phenylamine (500 mg) dissolved in toluene (15 ml) was treated with 3,5-dichlorophenylisocyanate (500 mg) and stirred for a week. The precipitated product was filtered, washed with toluene, dissolved in acetone, filtered through celite, precipitated again with water, filtered and dried. This residue was slurried in 96% EtOH, and adjusted to basic pH with 10 N NaOH. The solution was filtered through celite and re-acidified with 4N HCl and a little water. The precipitated product was filtered and washed with water to afford 1-[4-Chloro-2-(1H-tetrazol-5-yl)-phenyl]-3-(3,5-dichloro-phenyl)-urea as a white solid (720 mg ). Mp.=234-236° C.

Provenance & Evidence