1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → HCID 178522076, compound

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Reaction Steps

4-Chloro-2-(1H-tetrazol-5-yl)-phenylamine (500 mg) dissolved in toluene (15 ml) was treated with 4-chloro-3-trifluoromethylphenylisocyanate (600 mg) and stirred for a week. The precipitated product was filtered and then acid/base extracted and re-precipitated in aq. acid in a manner analogous to that described for 1-[4-Chloro-2-(1H-tetrazol-5-yl)-phenyl]-3-(3,5-dichloro-phenyl)-urea (Compound 12) to give 1-[4-Chloro-2-(IH-tetrazol-5-yl)-phenyl]-3-(4-chloro-3-trifluoromethyl-phenyl)-urea as a white solid (850 mg). Mp.=245-247° C.

Provenance & Evidence