Potassium Hydroxide → 4-(3-(2,6-Dimethylbenzyloxy)phenyl)4-oxobutyric acid Potassium salt

HRID 2262794Notes

Reaction equation

HRID 2262794 reaction equation
[CH3:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:18])[CH2:13][CH2:14][C:15]([OH:17])=[O:16])[CH:9]=[CH:10][CH:11]=1.[OH-].[K+:25]>C(O)C>[K+:25].[CH3:23][C:19]1[CH:20]=[CH:21][CH:22]=[C:2]([CH3:1])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:18])[CH2:13][CH2:14][C:15]([O-:17])=[O:16])[CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 9926783HCID 9926783, compound

Product 1

HCID 208123284-(3-(2,6-Dimethylbenzyloxy)phenyl)4-oxobutyric acid Potassium salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The 4-(3-(2,6-Dimethylbenzyloxy)phenyl)-4-oxobutyric acid (Step D, 6.0 g, 19.4 mmol) was dissolved in abs ethanol (20 ml) by warming gently followed by addition of KOH (1.21 g) at 0° C. temperature. The reaction mixture was stirred for one hour, concentrated in vaccuo and lyophilized to give the title compound as white solid.

Workup

  1. temperatureby warming gently
  2. concentrationconcentrated in vaccuo

Sources & evidence

ORD record
ord-b165b2842bf6430d96a73098ca151e2c
Source dataset
uspto-grants-2010_12
Patent number
US07851494B2

Reaction notes

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