Dapagliflozin → HCID 131728579, compound

HRID 2262861Notes

Reaction equation

HRID 2262861 reaction equation
[CH3:1][CH2:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]2[CH:12]=[C:13]([C@@H:18]3[O:23][C@H:22]([CH2:24][OH:25])[C@@H:21]([OH:26])[C@H:20]([OH:27])[C@H:19]3[OH:28])[CH:14]=[CH:15][C:16]=2[Cl:17])=[CH:8][CH:9]=1.[CH3:29][CH2:30][O:31][C:32]1[CH:37]=[CH:36][C:35]([CH2:38][C:39]2[CH:44]=[C:43]([CH:45]3[O:50][C@H:49]([CH2:51][OH:52])[C@@H:48]([OH:53])[C@H:47]([OH:54])[C@H:46]3[OH:55])[CH:42]=[CH:41][C:40]=2[Cl:56])=[CH:34][CH:33]=1.[CH3:57][C@H:58]([OH:61])[CH2:59][OH:60].[OH2:62]>>[CH3:1][CH2:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]2[CH:12]=[C:13]([C@@H:18]3[O:23][C@H:22]([CH2:24][OH:25])[C@@H:21]([OH:26])[C@H:20]([OH:27])[C@H:19]3[OH:28])[CH:14]=[CH:15][C:16]=2[Cl:17])=[CH:6][CH:5]=1.[CH3:29][CH2:30][O:31][C:32]1[CH:37]=[CH:36][C:35]([CH2:38][C:39]2[CH:44]=[C:43]([CH:45]3[O:50][C@H:49]([CH2:51][OH:52])[C@@H:48]([OH:53])[C@H:47]([OH:54])[C@H:46]3[OH:55])[CH:42]=[CH:41][C:40]=2[Cl:56])=[CH:34][CH:33]=1.[CH3:57][C@H:58]([OH:61])[CH2:59][OH:60].[OH2:62]

Participants

3

Reactant 2

HCID 9887712DapagliflozinHCID 56841155HCID 56841155, compound

Product 1

HCID 131728579HCID 131728579, compound

Procedure

Tablets containing the SGLT2 inhibitor dapagliflozin or dapagliflozin propylene glycol hydrate were prepared in strengths of 2.5 mg (Example 7), 10 mg (Example 8) and 50 mg (Example 9) as described below.

Workup

  1. customwere prepared in strengths of 2.5 mg (Example 7), 10 mg (Example 8) and 50 mg (Example 9)

Sources & evidence

ORD record
ord-8a289d7d3ce7407b91d46093fd53ae73
Source dataset
uspto-grants-2010_12
Patent number
US07851502B2

Reaction notes

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