Trifluoroacetic acid → N-1,2-Benzisoxazol-3-ylpiperazine-1-carboxamide trifluoroacetate

関与物質

反応手順

A solution of tert-butyl 4-[(1,2-benzisoxazol-3-ylamino)carbonyl]piperazine-1-carboxylate (16.5 g, 47.6 mmol) in trifluoroacetic acid (200 ml) was stirred at room temperature for 2 hours, and then the solvent was distilled off under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and diethyl ether to give 16.3 g (95.3%) of the desired product.

情報源と証拠