Water → HCID 68776400, compound

Participants

Reaction Steps

To a solution of 5-chloro-3-(2-fluorophenyl)-1,2,4-thiadiazole (119 mg, 0.555 mmol) and N-1,2-benzisoxazol-3-ylpiperazine-1-carboxamide trifluoroacetate (200 mg, 0.555 mmol) in N,N-dimethylformamide (2 ml) was added triethylamine (0.389 ml, 2.78 mmol) at room temperature, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was poured to water, and the desired product as a solid was separated by filtration, which was then recrystallized from a mixed solvent of ethyl acetate and tetrahydrofuran. Yield: 96.0 mg (40.9%).

Provenance & Evidence